The role of mitochondria in neurodegenerative diseases
M Filosto, M Scarpelli, MS Cotelli, V Vielmi… - Journal of …, 2011 - Springer
M Filosto, M Scarpelli, MS Cotelli, V Vielmi, A Todeschini, V Gregorelli, P Tonin, G Tomelleri…
Journal of neurology, 2011•SpringerMitochondria are implicated in several metabolic pathways including cell respiratory
processes, apoptosis, and free radical production. Mitochondrial abnormalities have been
documented in neurodegenerative diseases, including Alzheimer's, Parkinson's, and
Huntington's diseases, and amyotrophic lateral sclerosis. Several studies have
demonstrated that mitochondrial impairment plays an important role in the pathogenesis of
this group of disorders. In this review, we discuss the role of mitochondria in the main …
processes, apoptosis, and free radical production. Mitochondrial abnormalities have been
documented in neurodegenerative diseases, including Alzheimer's, Parkinson's, and
Huntington's diseases, and amyotrophic lateral sclerosis. Several studies have
demonstrated that mitochondrial impairment plays an important role in the pathogenesis of
this group of disorders. In this review, we discuss the role of mitochondria in the main …
Abstract
Mitochondria are implicated in several metabolic pathways including cell respiratory processes, apoptosis, and free radical production. Mitochondrial abnormalities have been documented in neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases, and amyotrophic lateral sclerosis. Several studies have demonstrated that mitochondrial impairment plays an important role in the pathogenesis of this group of disorders. In this review, we discuss the role of mitochondria in the main neurodegenerative diseases and review the updated knowledge in this field.
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