Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss
H Xu, GW Robinson, J Huang, JYS Lim, H Zhang… - Nature …, 2015 - nature.com
H Xu, GW Robinson, J Huang, JYS Lim, H Zhang, JK Bass, A Broniscer, M Chintagumpala…
Nature genetics, 2015•nature.comTaking a genome-wide association study approach, we identified inherited genetic
variations in ACYP2 associated with cisplatin-related ototoxicity (rs1872328: P= 3.9× 10− 8,
hazard ratio= 4.5) in 238 children with newly diagnosed brain tumors, with independent
replication in 68 similarly treated children. The ACYP2 risk variant strongly predisposed
these patients to precipitous hearing loss and was related to ototoxicity severity. These
results point to new biology underlying the ototoxic effects of platinum agents.
variations in ACYP2 associated with cisplatin-related ototoxicity (rs1872328: P= 3.9× 10− 8,
hazard ratio= 4.5) in 238 children with newly diagnosed brain tumors, with independent
replication in 68 similarly treated children. The ACYP2 risk variant strongly predisposed
these patients to precipitous hearing loss and was related to ototoxicity severity. These
results point to new biology underlying the ototoxic effects of platinum agents.
Abstract
Taking a genome-wide association study approach, we identified inherited genetic variations in ACYP2 associated with cisplatin-related ototoxicity (rs1872328: P = 3.9 × 10−8, hazard ratio = 4.5) in 238 children with newly diagnosed brain tumors, with independent replication in 68 similarly treated children. The ACYP2 risk variant strongly predisposed these patients to precipitous hearing loss and was related to ototoxicity severity. These results point to new biology underlying the ototoxic effects of platinum agents.
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