Expression pattern of wolframin, the WFS1 (Wolfram syndrome-1 gene) product, in common marmoset (Callithrix jacchus) cochlea
Wolfram syndrome is an autosomal recessive disorder of the neuroendocrine system, known
as DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy and Deafness)
syndrome, and considered an endoplasmic reticulum disease. Patients show mutations in
WFS1, which encodes the 890 amino acid protein wolframin. Although Wfs1 knockout mice
develop diabetes, their hearing level is completely normal. In this study, we examined the
expression of wolframin in the cochlea of a nonhuman primate common marmoset (Callithrix …
as DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy and Deafness)
syndrome, and considered an endoplasmic reticulum disease. Patients show mutations in
WFS1, which encodes the 890 amino acid protein wolframin. Although Wfs1 knockout mice
develop diabetes, their hearing level is completely normal. In this study, we examined the
expression of wolframin in the cochlea of a nonhuman primate common marmoset (Callithrix …
