Nitric oxide prevents tumor necrosis factor α–induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of …
YM Kim, TH Kim, HT Chung, RV Talanian, XM Yin… - Hepatology, 2000 - Elsevier
Mitochondrial cytochrome c release plays a critical role in apoptotic signal cascade after the
activation of cell surface death receptors. We investigated the role played by nitric oxide
(NO) in mitochondrial apoptotic signaling in tumor necrosis factor α (TNF-α) plus actinomycin
D (TNF-α/ActD)-induced apoptosis. NO produced either by S-nitroso-N-acetyl-DL-
penicillamine (SNAP) or inducible NO synthase (iNOS) prevented TNF-α/ActD-induced
apoptosis in hepatocytes and also inhibited both caspase-8–like (IETDase) and caspase-3 …
activation of cell surface death receptors. We investigated the role played by nitric oxide
(NO) in mitochondrial apoptotic signaling in tumor necrosis factor α (TNF-α) plus actinomycin
D (TNF-α/ActD)-induced apoptosis. NO produced either by S-nitroso-N-acetyl-DL-
penicillamine (SNAP) or inducible NO synthase (iNOS) prevented TNF-α/ActD-induced
apoptosis in hepatocytes and also inhibited both caspase-8–like (IETDase) and caspase-3 …
